Product Description

MATRIX® Hi-Mineral is the ultimate three-way drench with unsurpassed efficacy against mixed infections of gastrointestinal parasites, including those with single or dual resistance to any of the three major drench families. Triple combinations have also been shown to significantly slow the development of drench resistance.

Contains

1 g/L abamectin, 40 g/L levamisole HCI, 22.7 g/L oxfendazole, 0.5 g/L selenium and 2.2 g/L cobalt.

Efficacy and triple combinations

Triple combination products contain three anthelmintics with a similar spectrum of activity and different mechanisms of action. There are two main justifications for the use of such combinations: (1) to enable the effective control of nematodes in the presence of single or multiple drug resistance, and (2) to slow the development of resistance to the individual component anthelmintic classes. If co-administered actives have independent modes of action and mechanisms of resistance, worms that survive one treatment will be killed by the other. This means that combinations achieve higher efficacy against resistant parasite populations than do any of the individual component anthelmintics used alone, and fewer resistant parasites survive treatment. In order for this to be effective, we must ensure that there are adequate numbers of sensitive parasites in refugia in order to dilute the resistant genes.

Dosage Guide ― Sheep

For sheep over 75 kg bw dose at 1 mL/5 kg. 1 mL/5 kg body weight delivering 0.2 mg/kg abamectin, 8 mg/kg levamisole HCI, 4.5 mg/kg oxfendazole, 0.1 mg/kg selenium and 0.44 mg/kg cobalt.